| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
COL2A1 |
| Gene ID: |
1280 |
| Uniprot ID: |
CO2A1_HUMAN |
| Immunogen Region: |
Asp1242-Leu1487 |
| Immunogen: |
Recombinant Human Collagen II alpha 1/COL2A1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp1242-Leu1487) of Human Collagen II alpha 1/COL2A1 (Accession #NP_149162.2) fused with a hFc tag at t |
| Immunogen Sequence: |
ERSLAGAEETIPLQTLRCYN DYTSHITCRWADTQDAQRLV NVTLIRRVNEDLLEPVSCDL SDDMPWSACPHPRCVPRRCV IPCQSFVVTDVDYFSFQPDR PLGTRLTVTLTQHVQPPEPR DLQISTDQDHFLLTWSVALG SPQSHWLSPGDLEFEVVYKR LQDSWEDAAILLSNTSQATL GPEHLMPSSTYVARVRTRLA PGSRLSGRPSKWSPEVCWDS QPGDEAQPQNLECFFDGAA |
| Tissue Specificity | Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. |
| Post Translational Modifications | The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX) chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL2. Contains mostly 4-hydroxyproline. Prolines at the third position of the tripeptide repeating unit (G-X-P) are 4-hydroxylated in some or all of the chains. Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains. O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide. |
| Function | Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. |
| Protein Name | Collagen Alpha-1(Ii ChainAlpha-1 Type Ii Collagen Cleaved Into - Collagen Alpha-1(Ii Chain - Chondrocalcin |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474244Reactome: R-HSA-1650814Reactome: R-HSA-186797Reactome: R-HSA-198933Reactome: R-HSA-2022090Reactome: R-HSA-216083Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-419037Reactome: R-HSA-8874081Reactome: R-HSA-8948216 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Collagen Alpha-1(Ii Chain proteinAlpha-1 Type Ii Collagen Cleaved Into - Collagen Alpha-1(Ii Chain - Chondrocalcin proteinCOL2A1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
