| Post Translational Modifications | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Isoform 2 contains an additional N-linked glycosylation site. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. Phosphorylated. Thought to be phosphorylated by CERT, but CERT does not have kinase activity. |
| Function | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity.these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. |
| Protein Name | Collagen Alpha-3(Iv ChainGoodpasture Antigen Cleaved Into - Tumstatin |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474244Reactome: R-HSA-1650814Reactome: R-HSA-186797Reactome: R-HSA-2022090Reactome: R-HSA-216083Reactome: R-HSA-2214320Reactome: R-HSA-2243919Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-419037Reactome: R-HSA-8948216 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneColocalizes With Col4a4 And Col4a5 In GbmTubular Basement Membrane (Tbm) And Synaptic Basal Lamina (Bl) |
| Alternative Protein Names | Collagen Alpha-3(Iv Chain proteinGoodpasture Antigen Cleaved Into - Tumstatin proteinCOL4A3 protein |
Information sourced from Uniprot.org
