Human COL17A1 protein (Recombinant) (C-His) (STJP010081)

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STJP010081
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human COL17A1-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: COL17A1
Gene ID: 1308
Uniprot ID: COHA1_HUMAN
Immunogen Region: Glu491-Arg563
Immunogen: Homo sapiens (Human)
Post Translational Modifications The intracellular/endo domain is disulfide-linked. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544.
Function May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Protein Name Collagen Alpha-1(Xvii Chain
180 Kda Bullous Pemphigoid Antigen 2
Bullous Pemphigoid Antigen 2 Cleaved Into - 120 Kda Linear Iga Disease Antigen
120 Kda Linear Iga Dermatosis Antigen
Linear Iga Disease Antigen 1
Lad-1 - 97 Kda Linear Iga Disease Antigen
97 Kda Linear Iga Bullous Dermatosis Antigen
97 Kda Lad Antigen
97-Lad
Linear Iga Bullous Disease Antigen Of 97 Kda
Labd97
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1650814
Reactome: R-HSA-198933
Reactome: R-HSA-2022090
Reactome: R-HSA-446107
Reactome: R-HSA-8948216
Cellular Localisation Cell Junction
Hemidesmosome
Membrane
Single-Pass Type Ii Membrane Protein
Localized Along The Plasma Membrane Of The Hemidesmosome
120 Kda Linear Iga Disease Antigen: Secreted
Extracellular Space
Extracellular Matrix
Basement Membrane
Exclusively Localized To Anchoring Filaments
Localized To The Epidermal Side Of Split Skin
97 Kda Linear Iga Disease Antigen: Secreted
Localized In The Lamina Lucida Beneath The Hemidesmosomes
Alternative Protein Names Collagen Alpha-1(Xvii Chain protein
180 Kda Bullous Pemphigoid Antigen 2 protein
Bullous Pemphigoid Antigen 2 Cleaved Into - 120 Kda Linear Iga Disease Antigen protein
120 Kda Linear Iga Dermatosis Antigen protein
Linear Iga Disease Antigen 1 protein
Lad-1 - 97 Kda Linear Iga Disease Antigen protein
97 Kda Linear Iga Bullous Dermatosis Antigen protein
97 Kda Lad Antigen protein
97-Lad protein
Linear Iga Bullous Disease Antigen Of 97 Kda protein
Labd97 protein
COL17A1 protein
BP180 protein
BPAG2 protein

Information sourced from Uniprot.org

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