Human CNOT2 protein (Recombinant) (N-His) (STJP009731)

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STJP009731
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CNOT2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CNOT2
Gene ID: 4848
Uniprot ID: CNOT2_HUMAN
Immunogen Region: Ala432-Phe540
Immunogen: Homo sapiens (Human)
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation.the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
Protein Name Ccr4-Not Transcription Complex Subunit 2
Ccr4-Associated Factor 2
Database Links Reactome: R-HSA-429947
Reactome: R-HSA-6804115
Reactome: R-HSA-9820841
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Ccr4-Not Transcription Complex Subunit 2 protein
Ccr4-Associated Factor 2 protein
CNOT2 protein
CDC36 protein
NOT2 protein
HSPC131 protein
MSTP046 protein

Information sourced from Uniprot.org

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