| Post Translational Modifications | N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes. Bis(monoacylglycero)phosphate synthase CLN5: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Bis(monoacylglycero)phosphate synthase CLN5, secreted form). Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end. |
| Function | Bis(monoacylglycero)phosphate synthase CLN5, secreted form: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation. |
| Protein Name | Bis(Monoacylglycerophosphate Synthase Cln5Bmp Synthase Cln5Ceroid-Lipofuscinosis Neuronal Protein 5Protein Cln5Palmitoyl Protein Thioesterase Cln5S-Depalmitoylase Cln5 Cleaved Into - Bis(Monoacylglycerophosphate Synthase Cln5 - Secreted Form |
| Cellular Localisation | Bis(Monoacylglycero)Phosphate Synthase Cln5Secreted Form: LysosomeBis(Monoacylglycero)Phosphate Synthase Cln5: MembraneSingle-Pass Type Ii Membrane ProteinAn Amphipathic Anchor Region Facilitates Its Association With The Membrane |
| Alternative Protein Names | Bis(Monoacylglycerophosphate Synthase Cln5 proteinBmp Synthase Cln5 proteinCeroid-Lipofuscinosis Neuronal Protein 5 proteinProtein Cln5 proteinPalmitoyl Protein Thioesterase Cln5 proteinS-Depalmitoylase Cln5 Cleaved Into - Bis(Monoacylglycerophosphate Synthase Cln5 - Secreted Form proteinCLN5 proteinBMPS protein |
Information sourced from Uniprot.org
