Human CLIC2 protein (Recombinant) (N-His) (STJP014260)

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STJP014260-100
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Host: E.coli
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CLIC2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 20% Glycerol, pH 8.0.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: CLIC2
Gene ID: 1193
Uniprot ID: CLIC2_HUMAN
Immunogen Region: Met1-Ser247
Immunogen: Homo sapiens (Human)
Function In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
Protein Name Chloride Intracellular Channel Protein 2
Glutaredoxin-Like Oxidoreductase Clic2
Glutaredoxin-Like Peroxidase Clic2
Xap121
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-5578775
Cellular Localisation Cytoplasm
Membrane
Single-Pass Membrane Protein
Exists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane Domain
Alternative Protein Names Chloride Intracellular Channel Protein 2 protein
Glutaredoxin-Like Oxidoreductase Clic2 protein
Glutaredoxin-Like Peroxidase Clic2 protein
Xap121 protein
CLIC2 protein

Information sourced from Uniprot.org

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