Human CLEC1B protein (Recombinant) (N-His) (STJP006119)

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STJP006119
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CLEC1B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CLEC1B
Gene ID: 51266
Uniprot ID: CLC1B_HUMAN
Immunogen Region: Val56-Pro229
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding.
Function C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
Protein Name C-Type Lectin Domain Family 1 Member B
C-Type Lectin-Like Receptor 2
Clec-2
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-9707616
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names C-Type Lectin Domain Family 1 Member B protein
C-Type Lectin-Like Receptor 2 protein
Clec-2 protein
CLEC1B protein
CLEC2 protein
UNQ721 protein
PRO1384 protein

Information sourced from Uniprot.org

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