Human CLCA1 protein (Recombinant) (N-His) (STJP003120)

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STJP003120
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CLCA1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CLCA1
Gene ID: 1179
Uniprot ID: CLCA1_HUMAN
Immunogen Region: Asn416-Arg670
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated. The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
Function May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Protein Name Calcium-Activated Chloride Channel Regulator 1
Calcium-Activated Chloride Channel Family Member 1
Hclca1
Calcium-Activated Chloride Channel Protein 1
Cacc-1
Hcacc-1
Database Links Reactome: R-HSA-2672351
Cellular Localisation Secreted
Extracellular Space
Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Protein That Remains Attached To The Plasma Membrane Appeared To Be Predominantly Localized To Microvilli
Alternative Protein Names Calcium-Activated Chloride Channel Regulator 1 protein
Calcium-Activated Chloride Channel Family Member 1 protein
Hclca1 protein
Calcium-Activated Chloride Channel Protein 1 protein
Cacc-1 protein
Hcacc-1 protein
CLCA1 protein
CACC1 protein

Information sourced from Uniprot.org

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