Human CLCA1 protein (Recombinant) (N-His) (STJP003120)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLCA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CLCA1 |
| Gene ID | 1179 |
| Uniprot ID | CLCA1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn416-Arg670 |
Additional Info
| Post Translational Modifications | Glycosylated. The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. |
| Function | May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 1Calcium-Activated Chloride Channel Family Member 1Hclca1Calcium-Activated Chloride Channel Protein 1Cacc-1Hcacc-1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular SideProtein That Remains Attached To The Plasma Membrane Appeared To Be Predominantly Localized To Microvilli |
| Alternative Protein Names | Calcium-Activated Chloride Channel Regulator 1 proteinCalcium-Activated Chloride Channel Family Member 1 proteinHclca1 proteinCalcium-Activated Chloride Channel Protein 1 proteinCacc-1 proteinHcacc-1 proteinCLCA1 proteinCACC1 protein |
Information sourced from Uniprot.org