Human CIP2A protein (Recombinant) (N-GST) (STJP005741)

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STJP005741
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Short Description :Recombinant-Human CIP2A-N-GST protein was developed from e.coli for the region N-GST. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:CIP2A
Gene ID:57650
Uniprot ID:CIP2A_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Glu560
Function Acts as an inhibitor of protein phosphatase PP2A. Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies. Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei. Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss.
Protein Name Protein Cip2a
Cancerous Inhibitor Of Pp2a
P90 Autoantigen
Database Links
Cellular Localisation Cytoplasm
Chromosome
Predominantly Localizes Within The Cytoplasm
Localizes To Broken Chromosomes Within Micronuclei During Interphase And Following Chromothripsis
Localization To Broken Chromosomes Is Mainly Independent Of Mdc1
Alternative Protein Names Protein Cip2a protein
Cancerous Inhibitor Of Pp2a protein
P90 Autoantigen protein
CIP2A protein
KIAA1524 protein

Information sourced from Uniprot.org

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