Human CILP protein (Recombinant) (N-GST) (STJP003348)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CILP-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CILP |
| Gene ID | 8483 |
| Uniprot ID | CILP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile603-Ala846 |
Additional Info
| Post Translational Modifications | Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. |
| Function | Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. |
| Protein Name | Cartilage Intermediate Layer Protein 1Cilp-1Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 |
| Database Links | Reactome: R-HSA-2404192 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Cartilage Intermediate Layer Protein 1 proteinCilp-1 proteinCartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 proteinCILP proteinUNQ602 proteinPRO1188 protein |
Information sourced from Uniprot.org