Human CILP protein (Recombinant) (N-GST) (STJP003348)

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STJP003348
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CILP-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CILP
Gene ID: 8483
Uniprot ID: CILP1_HUMAN
Immunogen Region: Ile603-Ala846
Immunogen: Homo sapiens (Human)
Post Translational Modifications Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.
Function Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Protein Name Cartilage Intermediate Layer Protein 1
Cilp-1
Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2
Database Links Reactome: R-HSA-2404192
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Protein Names Cartilage Intermediate Layer Protein 1 protein
Cilp-1 protein
Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 protein
CILP protein
UNQ602 protein
PRO1188 protein

Information sourced from Uniprot.org

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