| Function | Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis. Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells. Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing. Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells. Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea. Critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. |
| Protein Name | Calcium And Integrin-Binding Family Member 2Kinase-Interacting Protein 2Kip 2 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCell ProjectionStereociliumPhotoreceptor Inner SegmentCiliumPhotoreceptor Outer SegmentCell MembraneSarcolemmaColocalizes With Itga7 At The Myotendinous Junctions (Mtj) And At The Neuromuscular Junctions (Nmj)Located Mainly In Stereocilia And At The Apical Surface Of Hair Cells Of The CochleaLocalizes In The Cuticular Plate Along And At The Tip Of The Stereocilia Of Vestibular Sensory Hair Cells |
| Alternative Protein Names | Calcium And Integrin-Binding Family Member 2 proteinKinase-Interacting Protein 2 proteinKip 2 proteinCIB2 proteinKIP2 protein |
Information sourced from Uniprot.org
