| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CHD3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CHD3 |
| Gene ID: | 1107 |
| Uniprot ID: | CHD3_HUMAN |
| Immunogen Region: | Cys382-Phe573 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Sumoylation at Lys-1971 results in dissociation from chromatin and suppression of transcriptional repression. |
| Function | ATP-dependent helicase that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Involved in transcriptional repression as part of the NuRD complex. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 3Chd-3Atp-Dependent Helicase Chd3Mi-2 Autoantigen 240 Kda ProteinMi2-AlphaZinc Finger HelicaseHzfh |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-4551638Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusPml BodyCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeAssociates With Centrosomes In Interphase And MitosisLocalizes To Sites Of Dna Damage |
| Alternative Protein Names | Chromodomain-Helicase-Dna-Binding Protein 3 proteinChd-3 proteinAtp-Dependent Helicase Chd3 proteinMi-2 Autoantigen 240 Kda Protein proteinMi2-Alpha proteinZinc Finger Helicase proteinHzfh proteinCHD3 protein |
Information sourced from Uniprot.org
