| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CFL2-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CFL2 |
| Gene ID: | 1073 |
| Uniprot ID: | COF2_HUMAN |
| Immunogen Region: | Ala2-Leu166 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. |
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. |
| Protein Name | Cofilin-2Cofilin - Muscle Isoform |
| Database Links | |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonColocalizes With Cspr3 In The Z Line Of Sarcomeres |
| Alternative Protein Names | Cofilin-2 proteinCofilin - Muscle Isoform proteinCFL2 protein |
Information sourced from Uniprot.org