| Post Translational Modifications | There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully. |
| Function | Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney. |
| Protein Name | Centrosomal Protein Of 55 KdaCep55Up-Regulated In Colon Cancer 6 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCleavage FurrowMidbodyMidbody RingPresent At The Centrosomes At InterphaseA Small Portion Is Associated Preferentially With The Mother CentrioleWhereas The Majority Localizes To The Pericentriolar MaterialDuring MitosisLoses Affinity For The Centrosome At The Onset Of Prophase And Diffuses Throughout The CellThis Dissociation From The Centrosome Is Phosphorylation-DependentMay Remain Localized At The Centrosome During Mitosis In Certain Cell TypesAppears At The Cleavage Furrow In Late Anaphase And In The Midbody In Cytokinesis |
| Alternative Protein Names | Centrosomal Protein Of 55 Kda proteinCep55 proteinUp-Regulated In Colon Cancer 6 proteinCEP55 proteinC10orf3 proteinURCC6 protein |
Information sourced from Uniprot.org
