Human CENPM protein (Recombinant) (His-Tag) (STJP019502)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CENPM-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CENPM |
| Gene ID | 79019 |
| Uniprot ID | CENPM_HUMAN |
| Accession Number | NP_076958 |
| Immunogen | Human |
| Immunogen Region | 1-180aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells. |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. |
| Protein Name | Centromere Protein MCenp-MInterphase Centromere Complex Protein 39Proliferation-Associated Nuclear Element Protein 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusCytoplasmChromosomeCentromereKinetochoreNuclear In Non-Confluent Cells And Cytoplasmic In Confluent Or Dividing CellsLocalizes In The Kinetochore Domain Of Centromeres |
| Alternative Protein Names | Centromere Protein M proteinCenp-M proteinInterphase Centromere Complex Protein 39 proteinProliferation-Associated Nuclear Element Protein 1 proteinCENPM proteinC22orf18 proteinICEN39 proteinPANE1 protein |
Information sourced from Uniprot.org