| Tissue Specificity | Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells. |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. |
| Protein Name | Centromere Protein MCenp-MInterphase Centromere Complex Protein 39Proliferation-Associated Nuclear Element Protein 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusCytoplasmChromosomeCentromereKinetochoreNuclear In Non-Confluent Cells And Cytoplasmic In Confluent Or Dividing CellsLocalizes In The Kinetochore Domain Of Centromeres |
| Alternative Protein Names | Centromere Protein M proteinCenp-M proteinInterphase Centromere Complex Protein 39 proteinProliferation-Associated Nuclear Element Protein 1 proteinCENPM proteinC22orf18 proteinICEN39 proteinPANE1 protein |
Information sourced from Uniprot.org
