| Post Translational Modifications | Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation. Ubiquitinated by BTRC.ubiquitination leads to endocytosis and subsequent degradation of IL10RA. |
| Function | Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy. |
| Protein Name | Interleukin-10 Receptor Subunit AlphaIl-10 Receptor Subunit AlphaIl-10r Subunit AlphaIl-10raCdw210aInterleukin-10 Receptor Subunit 1Il-10r Subunit 1Il-10r1Cd Antigen Cd210 |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9725371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasm |
| Alternative Protein Names | Interleukin-10 Receptor Subunit Alpha proteinIl-10 Receptor Subunit Alpha proteinIl-10r Subunit Alpha proteinIl-10ra proteinCdw210a proteinInterleukin-10 Receptor Subunit 1 proteinIl-10r Subunit 1 proteinIl-10r1 proteinCd Antigen Cd210 proteinIL10RA proteinIL10R protein |
Information sourced from Uniprot.org
