| Host: | E.coli |
| Applications: | SDS-PAGE/Denatured |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CDK3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1M urea, 10% Glycerol |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDK3 |
| Gene ID: | 1018 |
| Uniprot ID: | CDK3_HUMAN |
| Immunogen Region: | 1-305aa |
| Accession Number: | NP_001249 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDMFQKV EKIGEGTYGV VYKAKNRETG QLVALKKIRL DLEMEGVPST AIREISLLKE LKHPNIVRLL DVVHNERKLY LVFEFLSQDL KKYMDSTPGS ELPLHLIKSY LFQLLQGVSF CHSHRVIHRD LKPQNLLINE LGAIKLADFG LARAFGVPLR TYTHEVVTLW YRAPEILLGS KFYTTAVDIW SIGCIFAEMV TRKALFPG |
| Tissue Specificity | Expressed in cancer cell lines and glioblastoma tissue. |
| Function | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle.involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
| Protein Name | Cyclin-Dependent Kinase 3Cell Division Protein Kinase 3 |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | Cyclin-Dependent Kinase 3 proteinCell Division Protein Kinase 3 proteinCDK3 proteinCDKN3 protein |
Information sourced from Uniprot.org