Human CD85k/LILRB4/ILT3 protein (Recombinant) (C-His) (STJP005732)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD85k/LILRB4/ILT3-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LILRB4 |
| Gene ID | 11006 |
| Uniprot ID | LIRB4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Glu259 |
Additional Info
| Function | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production. This inhibition of monocyte activation occurs at least in part via binding to FN1. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytotoxic T cells and enhancing the generation of CD8+ T suppressor cells. Induces up-regulation of CD86 on dendritic cells. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4B4Cd85 Antigen-Like Family Member KImmunoglobulin-Like Transcript 3Ilt-3Leukocyte Immunoglobulin-Like Receptor 5Lir-5Monocyte Inhibitory Receptor Hm18Cd Antigen Cd85k |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLigand Binding Leads To Internalization And Translocation To An Antigen-Processing Compartment |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 proteinB4 proteinCd85 Antigen-Like Family Member K proteinImmunoglobulin-Like Transcript 3 proteinIlt-3 proteinLeukocyte Immunoglobulin-Like Receptor 5 proteinLir-5 proteinMonocyte Inhibitory Receptor Hm18 proteinCd Antigen Cd85k proteinLILRB4 proteinILT3 proteinLIR5 protein |
Information sourced from Uniprot.org