| Tissue Specificity | Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells. |
| Post Translational Modifications | Glycosylated when expressed on activated dendritic cells. |
| Function | Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections. |
| Protein Name | Cd83 AntigenHcd83B-Cell Activation ProteinCell Surface Protein Hb15Cd Antigen Cd83 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative ELISA Names | Cd83 Antigen ELISA kitHcd83 ELISA kitB-Cell Activation Protein ELISA kitCell Surface Protein Hb15 ELISA kitCd Antigen Cd83 ELISA kitCD83 ELISA kit |
| output | |
Information sourced from Uniprot.org
