Human CD72 protein (Recombinant) (N-His) (STJP009514)

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STJP009514
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Short Description :Recombinant-Human CD72-N-His protein was developed from mammalian cells for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:CD72
Gene ID:971
Uniprot ID:CD72_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Arg117-Asp359
Post Translational Modifications Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1.
Function Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis.
Protein Name B-Cell Differentiation Antigen Cd72
Lyb-2
Cd Antigen Cd72
Database Links Reactome: R-HSA-416700
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names B-Cell Differentiation Antigen Cd72 protein
Lyb-2 protein
Cd Antigen Cd72 protein
CD72 protein

Information sourced from Uniprot.org

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