Human CD72 protein (Recombinant-Active) (C-hFc-His) (STJP011922)

SKU:
STJP011922-100
£553.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human CD72-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: CD72
Gene ID: 971
Uniprot ID: CD72_HUMAN
Immunogen Region: Arg117-Asp359
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1.
Function Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Acts also as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis.
Protein Name B-Cell Differentiation Antigen Cd72
Lyb-2
Cd Antigen Cd72
Database Links Reactome: R-HSA-416700
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names B-Cell Differentiation Antigen Cd72 protein
Lyb-2 protein
Cd Antigen Cd72 protein
CD72 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP011908 Human CD22 protein (Recombinant-Active) (C-hFc-His) (STJP011908) Mammalian Cells
STJP011981 Human LTBR protein (Recombinant-Active) (C-hFc-His) (STJP011981) Mammalian Cells
STJP012239 Human IL12RB2 protein (Recombinant-Active) (C-hFc-His) (STJP012239) Mammalian Cells
STJP012204 Human IL17RC protein (Recombinant-Active) (C-hFc-His) (STJP012204) Mammalian Cells
STJP012027 Human EFNA4 protein (Recombinant-Active) (C-hFc-His) (STJP012027) Mammalian Cells

Related Products

!