Human CD72 (Cluster Of Differentiation 72) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014197)

Human CD72 (Cluster Of Differentiation 72) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014197)

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STJE0014197
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Short Description :This CD72 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Applications:ELISA
Reactivity:Human
Sensitivity:0.055ng/mL
Detection Limit:0.156-10ng/mL
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Storage Instruction:The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:3 hrs
Gene Symbol:CD72
Gene ID:971
Uniprot ID:CD72_HUMAN
Immunogen Region:Ready-To-Use
Sample Type:tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Post Translational Modifications Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1.
Function Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis.
Protein Name B-Cell Differentiation Antigen Cd72
Lyb-2
Cd Antigen Cd72
Database Links Reactome: R-HSA-416700
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative ELISA Names B-Cell Differentiation Antigen Cd72 ELISA kit
Lyb-2 ELISA kit
Cd Antigen Cd72 ELISA kit
CD72 ELISA kit
output

Information sourced from Uniprot.org

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