Name: Human CD63 protein (Recombinant) (C-His) (STJP002835)
SKU: STJP002835
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Product Review

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g

Gene Symbol:	CD63
Gene ID:	967
Uniprot ID:	CD63_HUMAN
Immunogen Region:	Ala103-Val203
Immunogen:	Recombinant Human CD63 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala103-Val203) of human CD63 (Accession #NP_001771.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	AGYVFRDKVMSEFNNNFRQQ MENYPKNNHTASILDRMQAD FKCCGAANYTDWEKIPSMSK NRVPDSCCINVTVGCGINFN EKAIHKEGCVEKIGGWLRKN V

Post Translational Modifications	Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Function	Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Protein Name	Cd63 Antigen Granulophysin Lysosomal-Associated Membrane Protein 3 Lamp-3 Lysosome Integral Membrane Protein 1 Limp1 Melanoma-Associated Antigen Me491 Oma81h Ocular Melanoma-Associated Antigen Tetraspanin-30 Tspan-30 Cd Antigen Cd63
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Lysosome Membrane Late Endosome Membrane Endosome Multivesicular Body Melanosome Secreted Extracellular Exosome Cell Surface Also Found In Weibel-Palade Bodies Of Endothelial Cells Located In Platelet Dense Granules Detected In A Subset Of Pre-Melanosomes Detected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies
Alternative Protein Names	Cd63 Antigen protein Granulophysin protein Lysosomal-Associated Membrane Protein 3 protein Lamp-3 protein Lysosome Integral Membrane Protein 1 protein Limp1 protein Melanoma-Associated Antigen Me491 protein Oma81h protein Ocular Melanoma-Associated Antigen protein Tetraspanin-30 protein Tspan-30 protein Cd Antigen Cd63 protein CD63 protein MLA1 protein TSPAN30 protein

Information sourced from Uniprot.org

Human CD63 protein (Recombinant) (C-His) (STJP002835)

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