| Function | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. |
| Protein Name | Cd59 Glycoprotein1f5 Antigen20 Kda Homologous Restriction FactorHrf-20Hrf20Mac-Inhibitory ProteinMac-IpMem43 AntigenMembrane Attack Complex Inhibition FactorMacifMembrane Inhibitor Of Reactive LysisMirlProtectinCd Antigen Cd59 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedLocalizes To The Cell SurfaceSoluble Form Found In A Number Of Tissues |
| Alternative Protein Names | Cd59 Glycoprotein1f5 Antigen protein20 Kda Homologous Restriction Factor proteinHrf-20 proteinHrf20 proteinMac-Inhibitory Protein proteinMac-Ip proteinMem43 Antigen proteinMembrane Attack Complex Inhibition Factor proteinMacif proteinMembrane Inhibitor Of Reactive Lysis proteinMirl proteinProtectin proteinCd Antigen Cd59 proteinCD59 proteinMIC11 proteinMIN1 proteinMIN2 proteinMIN3 proteinMSK21 protein |
Information sourced from Uniprot.org
