Human CD59 protein (Recombinant) (C-His) (STJP007037)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD59-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CD59 |
| Gene ID | 966 |
| Uniprot ID | CD59_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Glu101 |
Additional Info
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. |
| Protein Name | Cd59 Glycoprotein1f5 Antigen20 Kda Homologous Restriction FactorHrf-20Hrf20Mac-Inhibitory ProteinMac-IpMem43 AntigenMembrane Attack Complex Inhibition FactorMacifMembrane Inhibitor Of Reactive LysisMirlProtectinCd Antigen Cd59 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedLocalizes To The Cell SurfaceSoluble Form Found In A Number Of Tissues |
| Alternative Protein Names | Cd59 Glycoprotein1f5 Antigen protein20 Kda Homologous Restriction Factor proteinHrf-20 proteinHrf20 proteinMac-Inhibitory Protein proteinMac-Ip proteinMem43 Antigen proteinMembrane Attack Complex Inhibition Factor proteinMacif proteinMembrane Inhibitor Of Reactive Lysis proteinMirl proteinProtectin proteinCd Antigen Cd59 proteinCD59 proteinMIC11 proteinMIN1 proteinMIN2 proteinMIN3 proteinMSK21 protein |
Information sourced from Uniprot.org