| Function | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. |
| Protein Name | Cd59 Glycoprotein1f5 Antigen20 Kda Homologous Restriction FactorHrf-20Hrf20Mac-Inhibitory ProteinMac-IpMem43 AntigenMembrane Attack Complex Inhibition FactorMacifMembrane Inhibitor Of Reactive LysisMirlProtectinCd Antigen Cd59 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSoluble Form Found In A Number Of Tissues |
| Alternative Protein Names | Cd59 Glycoprotein1f5 Antigen protein20 Kda Homologous Restriction Factor proteinHrf-20 proteinHrf20 proteinMac-Inhibitory Protein proteinMac-Ip proteinMem43 Antigen proteinMembrane Attack Complex Inhibition Factor proteinMacif proteinMembrane Inhibitor Of Reactive Lysis proteinMirl proteinProtectin proteinCd Antigen Cd59 proteinCD59 proteinMIC11 proteinMIN1 proteinMIN2 proteinMIN3 proteinMSK21 protein |
Information sourced from Uniprot.org
