• Biotinylated Human CD40 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human CD40 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Biotinylated Human CD40, His Tag at 1 Mu g/ml (100 Mu l/Well) on the plate. Dose response curve for Human CD40L, hFc Tag with the EC50 of 33ng/ml determined by ELISA.
  • Immobilized Biotinylated Human CD40, His Tag at 1 Mu g/ml (100 Mu l/Well) on the plate. Dose response curve for Human CD40L, hFc Tag with the EC50 of 33ng/ml determined by ELISA.
  • Serial dilutions of Anti-CD40 Antibody were added into Biotinylated Human CD40, His Tag : Human CD40 Ligand (Trimer) , hFc Tag binding reactioins. The half maximal inhibitiory concentration (IC50) is 2. 0ug/ml.

Human CD40/TNFRSF5 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001556)

SKU:
STJP001556

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD40/TNFRSF5-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CD40
Gene ID: 958
Uniprot ID: TNR5_HUMAN
Immunogen Region: Glu21-Arg193
Immunogen: DNA sequence encoding Human CD40/TNFRSF5 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 5
B-Cell Surface Antigen Cd40
Bp50
Cd40l Receptor
Cdw40
Cd Antigen Cd40
Database Links Reactome: R-HSA-198933 P25942-1
Reactome: R-HSA-5668541 P25942-1
Reactome: R-HSA-5676594 P25942-1
Cellular Localisation Isoform I: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Ii: Secreted
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 5 protein
B-Cell Surface Antigen Cd40 protein
Bp50 protein
Cd40l Receptor protein
Cdw40 protein
Cd Antigen Cd40 protein
CD40 protein
TNFRSF5 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance