| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized Human CD38 Protein at 1 Mu g/mL (100 Mu L/well) can bind CD38 Rabbit pAb with a linear range of 0.244-3.2 ng/mL.|2.Loaded CD38 Rabbit mAb on ProA Biosensor, can bind Human CD38 Prot |
| Gene Symbol: |
CD38 |
| Gene ID: |
952 |
| Uniprot ID: |
CD38_HUMAN |
| Immunogen Region: |
Val43-Ile300 |
| Immunogen: |
Recombinant Human CD38 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val43-Ile300) of human CD38 (Accession #NP_001766.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
VPRWRQQWSGPGTTKRFPET VLARCVKYTEIHPEMRHVDC QSVWDAFKGAFISKHPCNIT EEDYQPLMKLGTQTVPCNKI LLWSRIKDLAHQFTQVQRDM FTLEDTLLGYLADDLTWCGE FNTSKINYQSCPDWRKDCSN NPVSVFWKTVSRRFAEAACD VVHVMLNGSRSKIFDKNSTF GSVEVHNLQPEKVQTLEAWV IHGGREDSRDLCQDPTIKEL ESIISKRNIQFSCKNIYRP |
| Tissue Specificity | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. |
| Function | Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. |
| Protein Name | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 12'-Phospho-Adp-Ribosyl Cyclase2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase2'-Phospho-Cyclic-Adp-Ribose TransferaseAdp-Ribosyl Cyclase 1Adprc 1Cyclic Adp-Ribose Hydrolase 1Cadpr Hydrolase 1T10Cd Antigen Cd38 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Cell SurfaceMembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 protein2'-Phospho-Adp-Ribosyl Cyclase protein2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase protein2'-Phospho-Cyclic-Adp-Ribose Transferase proteinAdp-Ribosyl Cyclase 1 proteinAdprc 1 proteinCyclic Adp-Ribose Hydrolase 1 proteinCadpr Hydrolase 1 proteinT10 proteinCd Antigen Cd38 proteinCD38 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
