| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells. |
| Protein Name | C-Type Lectin Domain Family 4 Member DC-Type Lectin Superfamily Member 8C-Type Lectin-Like Receptor 6Clec-6Dendritic Cell-Associated C-Type Lectin 3Dc-Associated C-Type Lectin 3Dectin-3Cd Antigen Cd368 |
| Database Links | Reactome: R-HSA-5621480Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | C-Type Lectin Domain Family 4 Member D proteinC-Type Lectin Superfamily Member 8 proteinC-Type Lectin-Like Receptor 6 proteinClec-6 proteinDendritic Cell-Associated C-Type Lectin 3 proteinDc-Associated C-Type Lectin 3 proteinDectin-3 proteinCd Antigen Cd368 proteinCLEC4D proteinCLECSF8 proteinMCL protein |
Information sourced from Uniprot.org
