Human CD350/FZD10 protein (Recombinant) (C-His) (STJP007152)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD350/FZD10-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FZD10 |
| Gene ID | 11211 |
| Uniprot ID | FZD10_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Gly161 |
Additional Info
| Post Translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function | Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). |
| Protein Name | Frizzled-10Fz-10Hfz10Fze7Cd Antigen Cd350 |
| Database Links | Reactome: R-HSA-373080 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Frizzled-10 proteinFz-10 proteinHfz10 proteinFze7 proteinCd Antigen Cd350 proteinFZD10 protein |
Information sourced from Uniprot.org