Human CD332/FGFR2 protein (Recombinant) (N-His) (STJP004325)

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STJP004325
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD332/FGFR2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FGFR2
Gene ID: 2263
Uniprot ID: FGFR2_HUMAN
Immunogen Region: Arg22-Glu377
Immunogen: Homo sapiens (Human)
Function Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Protein Name Fibroblast Growth Factor Receptor 2
Fgfr-2
K-Sam
Kgfr
Keratinocyte Growth Factor Receptor
Cd Antigen Cd332
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-190375
Reactome: R-HSA-190377
Reactome: R-HSA-2023837
Reactome: R-HSA-2033519
Reactome: R-HSA-2219530
Reactome: R-HSA-5654221
Reactome: R-HSA-5654695
Reactome: R-HSA-5654699
Reactome: R-HSA-5654700
Reactome: R-HSA-5654727
Reactome: R-HSA-5655253
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-8851708
Reactome: R-HSA-8853333
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Cytoplasmic Vesicle
Detected On Osteoblast Plasma Membrane Lipid Rafts
After Ligand Binding
The Activated Receptor Is Rapidly Internalized And Degraded
Isoform 1: Cell Membrane
Isoform 3: Cell Membrane
Isoform 8: Secreted
Isoform 13: Secreted
Alternative Protein Names Fibroblast Growth Factor Receptor 2 protein
Fgfr-2 protein
K-Sam protein
Kgfr protein
Keratinocyte Growth Factor Receptor protein
Cd Antigen Cd332 protein
FGFR2 protein
BEK protein
KGFR protein
KSAM protein

Information sourced from Uniprot.org

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