Human CD326/EPCAM protein (Recombinant-Active) (C-His) (STJP011889)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD326/EPCAM-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by the ability of the Immobilised protein to support the adhesion of mouse embryonic fibroblast cells (NIH-3T3). When cells are added to CD326/EPCAM coated plates (1.25 Mu g/mL, 100 Mu L/well) , approximately >30% will adhere specifically af |
Target Information
| Gene Symbol | EPCAM |
| Gene ID | 4072 |
| Uniprot ID | EPCAM_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln24-Lys265 |
Additional Info
| Post Translational Modifications | Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability. |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
| Protein Name | Epithelial Cell Adhesion MoleculeEp-CamAdenocarcinoma-Associated AntigenCell Surface Glycoprotein Trop-1Epithelial Cell Surface AntigenEpithelial GlycoproteinEgpEpithelial Glycoprotein 314Egp314Hegp314Ks 1/4 AntigenKsaMajor Gastrointestinal Tumor-Associated Protein Ga733-2Tumor-Associated Calcium Signal Transducer 1Cd Antigen Cd326 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Lateral Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionColocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction |
| Alternative Protein Names | Epithelial Cell Adhesion Molecule proteinEp-Cam proteinAdenocarcinoma-Associated Antigen proteinCell Surface Glycoprotein Trop-1 proteinEpithelial Cell Surface Antigen proteinEpithelial GlycoproteinEgp proteinEpithelial Glycoprotein 314 proteinEgp314 proteinHegp314 proteinKs 1/4 Antigen proteinKsa proteinMajor Gastrointestinal Tumor-Associated Protein Ga733-2 proteinTumor-Associated Calcium Signal Transducer 1 proteinCd Antigen Cd326 proteinEPCAM proteinGA733-2 proteinM1S2 proteinM4S1 proteinMIC18 proteinTACSTD1 proteinTROP1 protein |
Information sourced from Uniprot.org