Human CD326/EPCAM protein (Recombinant-Active) (C-His) (STJP011889)

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STJP011889-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human CD326/EPCAM-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: EPCAM
Gene ID: 4072
Uniprot ID: EPCAM_HUMAN
Immunogen Region: Gln24-Lys265
Immunogen: Homo sapiens (Human)
Post Translational Modifications Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Protein Name Epithelial Cell Adhesion Molecule
Ep-Cam
Adenocarcinoma-Associated Antigen
Cell Surface Glycoprotein Trop-1
Epithelial Cell Surface Antigen
Epithelial Glycoprotein
Egp
Epithelial Glycoprotein 314
Egp314
Hegp314
Ks 1/4 Antigen
Ksa
Major Gastrointestinal Tumor-Associated Protein Ga733-2
Tumor-Associated Calcium Signal Transducer 1
Cd Antigen Cd326
Database Links Reactome: R-HSA-202733
Cellular Localisation Lateral Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Tight Junction
Colocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction
Alternative Protein Names Epithelial Cell Adhesion Molecule protein
Ep-Cam protein
Adenocarcinoma-Associated Antigen protein
Cell Surface Glycoprotein Trop-1 protein
Epithelial Cell Surface Antigen protein
Epithelial Glycoprotein
Egp protein
Epithelial Glycoprotein 314 protein
Egp314 protein
Hegp314 protein
Ks 1/4 Antigen protein
Ksa protein
Major Gastrointestinal Tumor-Associated Protein Ga733-2 protein
Tumor-Associated Calcium Signal Transducer 1 protein
Cd Antigen Cd326 protein
EPCAM protein
GA733-2 protein
M1S2 protein
M4S1 protein
MIC18 protein
TACSTD1 protein
TROP1 protein

Information sourced from Uniprot.org

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