| Post Translational Modifications | Phosphorylated on tyrosine. |
| Function | Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. |
| Protein Name | Cmrf35-Like Molecule 1Clm-1Cd300 Antigen-Like Family Member FImmune Receptor Expressed On Myeloid Cells 1Irem-1Immunoglobulin Superfamily Member 13Igsf13Nk Inhibitory ReceptorCd Antigen Cd300f |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cmrf35-Like Molecule 1 proteinClm-1 proteinCd300 Antigen-Like Family Member F proteinImmune Receptor Expressed On Myeloid Cells 1 proteinIrem-1 proteinImmunoglobulin Superfamily Member 13 proteinIgsf13 proteinNk Inhibitory Receptor proteinCd Antigen Cd300f proteinCD300LF proteinCD300F proteinCLM1 proteinIGSF13 proteinIREM1 proteinNKIR proteinUNQ3105 proteinPRO10111 protein |
Information sourced from Uniprot.org
