| Post Translational Modifications | Phosphorylated on tyrosine residues.probably by c-Abl, Fyn and c-Src. |
| Function | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation. |
| Protein Name | Cd2-Associated ProteinAdapter Protein CmsCas Ligand With Multiple Sh3 Domains |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffleCell JunctionColocalizes With F-Actin And Bcar1/P130cas In Membrane RufflesLocated At Podocyte Slit Diaphragm Between Podocyte Foot ProcessesDuring Late Anaphase And TelophaseConcentrates In The Vicinity Of The Midzone Microtubules And In The Midbody In Late Telophase |
| Alternative Protein Names | Cd2-Associated Protein proteinAdapter Protein Cms proteinCas Ligand With Multiple Sh3 Domains proteinCD2AP protein |
Information sourced from Uniprot.org
