Human CD2AP protein (Recombinant) (N-His-SUMO) (STJP008884)

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STJP008884
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD2AP-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CD2AP
Gene ID: 23607
Uniprot ID: CD2AP_HUMAN
Immunogen Region: Val2-Lys58
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on tyrosine residues.probably by c-Abl, Fyn and c-Src.
Function Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation.
Protein Name Cd2-Associated Protein
Adapter Protein Cms
Cas Ligand With Multiple Sh3 Domains
Database Links Reactome: R-HSA-373753
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Ruffle
Cell Junction
Colocalizes With F-Actin And Bcar1/P130cas In Membrane Ruffles
Located At Podocyte Slit Diaphragm Between Podocyte Foot Processes
During Late Anaphase And Telophase
Concentrates In The Vicinity Of The Midzone Microtubules And In The Midbody In Late Telophase
Alternative Protein Names Cd2-Associated Protein protein
Adapter Protein Cms protein
Cas Ligand With Multiple Sh3 Domains protein
CD2AP protein

Information sourced from Uniprot.org