| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CD283/TLR3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TLR3 |
| Gene ID: | 7098 |
| Uniprot ID: | TLR3_HUMAN |
| Immunogen Region: | Lys27-Ser711 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. Ubiquitinated by TRIM3.leading to recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. Ubiquitinated by ZNRF1 via 'Lys-63'-linked ubiquitin chains.leading to TLR3 lysosomal trafficking and degradation. Ubiquitinated by RNF170 at Lys-765 via 'Lys-48'-linked ubiquitin chains.leading to TLR3 proteasomal degradation. |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. |
| Protein Name | Toll-Like Receptor 3Cd Antigen Cd283 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-168164Reactome: R-HSA-168927Reactome: R-HSA-1810476Reactome: R-HSA-5602410Reactome: R-HSA-5602415Reactome: R-HSA-5602566Reactome: R-HSA-5602571Reactome: R-HSA-9013957Reactome: R-HSA-9013973Reactome: R-HSA-9014325Reactome: R-HSA-9828211Reactome: R-HSA-9833110 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneEarly Endosome |
| Alternative Protein Names | Toll-Like Receptor 3 proteinCd Antigen Cd283 proteinTLR3 protein |
Information sourced from Uniprot.org