Human CD280/MRC2 protein (Recombinant) (N-His) (STJP006706)

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STJP006706
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD280/MRC2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MRC2
Gene ID: 9902
Uniprot ID: MRC2_HUMAN
Immunogen Region: Pro41-Lys505
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated.
Function May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Protein Name C-Type Mannose Receptor 2
C-Type Lectin Domain Family 13 Member E
Endocytic Receptor 180
Macrophage Mannose Receptor 2
Urokinase-Type Plasminogen Activator Receptor-Associated Protein
Upar-Associated Protein
Urokinase Receptor-Associated Protein
Cd Antigen Cd280
Database Links Reactome: R-HSA-1236978
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names C-Type Mannose Receptor 2 protein
C-Type Lectin Domain Family 13 Member E protein
Endocytic Receptor 180 protein
Macrophage Mannose Receptor 2 protein
Urokinase-Type Plasminogen Activator Receptor-Associated Protein protein
Upar-Associated Protein protein
Urokinase Receptor-Associated Protein protein
Cd Antigen Cd280 protein
MRC2 protein
CLEC13E protein
ENDO180 protein
KIAA0709 protein
UPARAP protein

Information sourced from Uniprot.org

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