Human CD271/NGFR protein (Recombinant) (N-His) (STJP003822)

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STJP003822
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD271/NGFR-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NGFR
Gene ID: 4804
Uniprot ID: TNR16_HUMAN
Immunogen Region: Lys29-Asn250
Immunogen: Homo sapiens (Human)
Function Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 16
Gp80-Lngfr
Low Affinity Neurotrophin Receptor P75ntr
Low-Affinity Nerve Growth Factor Receptor
Ngf Receptor
Low-Affinity Nerve Growth Factor Receptor P75ngfr
Low-Affinity Nerve Growth Factor Receptor P75ngr
P75 Icd
Cd Antigen Cd271
Database Links Reactome: R-HSA-193634
Reactome: R-HSA-193648
Reactome: R-HSA-193670
Reactome: R-HSA-193681
Reactome: R-HSA-193692
Reactome: R-HSA-205017
Reactome: R-HSA-205025
Reactome: R-HSA-205043
Reactome: R-HSA-209543
Reactome: R-HSA-209560
Reactome: R-HSA-209563
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Perikaryon
Cell Projection
Growth Cone
Dendritic Spine
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 16 protein
Gp80-Lngfr protein
Low Affinity Neurotrophin Receptor P75ntr protein
Low-Affinity Nerve Growth Factor Receptor protein
Ngf Receptor protein
Low-Affinity Nerve Growth Factor Receptor P75ngfr protein
Low-Affinity Nerve Growth Factor Receptor P75ngr protein
P75 Icd protein
Cd Antigen Cd271 protein
NGFR protein
TNFRSF16 protein

Information sourced from Uniprot.org