Human CD27 protein (Recombinant) (C-Fc-His) (STJP013273)

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STJP013273-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD27-C-Fc-His protein was developed from mammalian cells and has a target region of C-Fc-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: CD27
Gene ID: 939
Uniprot ID: CD27_HUMAN
Immunogen Region: Thr21-Ile192
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Function Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
Protein Name Cd27 Antigen
Cd27l Receptor
T-Cell Activation Antigen Cd27
T14
Tumor Necrosis Factor Receptor Superfamily Member 7
Cd Antigen Cd27
Database Links Reactome: R-HSA-5669034
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Cd27 Antigen protein
Cd27l Receptor protein
T-Cell Activation Antigen Cd27 protein
T14 protein
Tumor Necrosis Factor Receptor Superfamily Member 7 protein
Cd Antigen Cd27 protein
CD27 protein
TNFRSF7 protein

Information sourced from Uniprot.org

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