Name: Human CD261/TNFRSF10A protein (Recombinant) (C-Fc) (STJP006988)
SKU: STJP006988
Availability: InStock

Human CD261/TNFRSF10A protein (Recombinant) (C-Fc) (STJP006988)

SKU:

STJP006988

£469.50 - £2,492.50

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Host:	Mammalian Cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human CD261/TNFRSF10A-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	Palmitoylated. Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death. Palmitoylated by ZDHHC3 (Probable).
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Protein Name	Tumor Necrosis Factor Receptor Superfamily Member 10a Death Receptor 4 Tnf-Related Apoptosis-Inducing Ligand Receptor 1 Trail Receptor 1 Trail-R1 Cd Antigen Cd261
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-202733 Reactome: R-HSA-3371378 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-6803211 Reactome: R-HSA-69416 Reactome: R-HSA-75158
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Cytoplasm Cytosol Palmitoylation Is Required For Association With Membranes
Alternative Protein Names	Tumor Necrosis Factor Receptor Superfamily Member 10a protein Death Receptor 4 protein Tnf-Related Apoptosis-Inducing Ligand Receptor 1 protein Trail Receptor 1 protein Trail-R1 protein Cd Antigen Cd261 protein TNFRSF10A protein APO2 protein DR4 protein TRAILR1 protein

Information sourced from Uniprot.org

Model	Name	Host	Clonality	Reactivity	Application
STJP011710	Human CD261/TNFRSF10A protein (Recombinant-Active) (C-hFc-His) (STJP011710)	Mammalian Cells
STJP002037	Human TRAIL-R1/CD261 protein (Recombinant) (C-His) (STJP002037)	HEK293 cells
STJA0027200	Anti-CD261/TNFRSF10A/DR4 antibody [SAA0083] (STJA0027200)	Human	Monoclonal	Human	FC
STJP008619	Human CD8B protein (Recombinant) (C-Fc) (STJP008619)	Mammalian Cells
STJP010134	Human PDE6D protein (Recombinant) (C-Fc) (STJP010134)	Mammalian Cells

Human CD261/TNFRSF10A protein (Recombinant) (C-Fc) (STJP006988)

General Information