Human CD226 (DNAM-1) protein (Recombinant) (STJP000612)

Name: Human CD226 (DNAM-1) protein (Recombinant) (STJP000612)
SKU: STJP000612
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostHEK293

ConjugationUnconjugated

ImmunogenOptimized DNA sequence encoding extracellular domain of HumanCD226 (DNAM-1) including a C-terminal His tag was expressed in HEK293 cells. NA

STJP000612

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Short Description	Recombinant-Human CD226 (DNAM-1)-protein was developed from hek293. For use in research applications.
Host	HEK293
Note	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Formulation	Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity	Recombinant Human CD226 activity was measured using Immobilized Human CD226 at 2 Mu g/ml ability to bind biotinylated Human CD112 with a linear ranger of 0.06-0.8 Mu g/ml NA

Gene Symbol	CD226
Gene ID	10666
Uniprot ID	CD226_HUMAN
Immunogen	Optimized DNA sequence encoding extracellular domain of HumanCD226 (DNAM-1) including a C-terminal His tag was expressed in HEK293 cells. NA
Immunogen Region	ECD

Tissue Specificity	Expressed by peripheral blood T-lymphocytes.
Post Translational Modifications	PKC-mediated phosphorylation at Ser-329 is required for lipid raft recruitment. Phosphorylation of Tyr-322 requires association with lipid rafts and allows GRB2 binding and activation of subsequent signaling.
Function	Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes.
Protein Name	Cd226 Antigen Dnax Accessory Molecule 1 Dnam-1 Cd Antigen Cd226
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Localizes To Lipid Rafts
Alternative Protein Names	Cd226 Antigen protein Dnax Accessory Molecule 1 protein Dnam-1 protein Cd Antigen Cd226 protein CD226 protein DNAM1 protein

Information sourced from Uniprot.org