Human CD203c/ENPP3 protein (Recombinant) (N-His) (STJP003185)

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STJP003185
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD203c/ENPP3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ENPP3
Gene ID: 5169
Uniprot ID: ENPP3_HUMAN
Immunogen Region: Met640-Pro857
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal.
Function Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3
E-Npp 3
Npp3
Alkaline Phosphodiesterase I
Dinucleoside Polyphosphatase
Nucleotide Diphosphatase
Nucleotide Pyrophosphatase
Nppase
Phosphodiesterase I Beta
Pd-Ibeta
Phosphodiesterase I/Nucleotide Pyrophosphatase 3
Cd Antigen Cd203c
Database Links Reactome: R-HSA-199220
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Apical Cell Membrane
Secreted
Detected At The Cell Surface Of Basophils
Detected At The Apical Plasma Membrane Of Bile Duct Cells
Located To The Apical Surface In Intestinal And Kidney Epithelial Cells
Secreted In Serum
And In Lumen Of Epithelial Cells
Alternative Protein Names Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 protein
E-Npp 3 protein
Npp3 protein
Alkaline Phosphodiesterase I protein
Dinucleoside Polyphosphatase protein
Nucleotide Diphosphatase protein
Nucleotide Pyrophosphatase protein
Nppase protein
Phosphodiesterase I Beta protein
Pd-Ibeta protein
Phosphodiesterase I/Nucleotide Pyrophosphatase 3 protein
Cd Antigen Cd203c protein
ENPP3 protein
PDNP3 protein

Information sourced from Uniprot.org

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