Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Active Recombinant-Human CD200R1-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human CD200 at 2 Mu g/mL (100 Mu L/well) can bind Human CD200 R with a linear range of 0.058-8.34 ng/mL. |
Gene Symbol: |
CD200R1 |
Gene ID: |
131450 |
Uniprot ID: |
MO2R1_HUMAN |
Immunogen: |
Recombinant Human CD200R1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala27-Leu266) of human CD200R/MOX2R (Accession #NP_620161.1) fused with a Fc, 6×His tag at the C-terminus. |
Function | Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. |
Protein Name | Cell Surface Glycoprotein Cd200 Receptor 1Cd200 Cell Surface Glycoprotein ReceptorCell Surface Glycoprotein Ox2 Receptor 1 |
Database Links | Reactome: R-HSA-198933 |
Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Cell MembraneIsoform 2: SecretedIsoform 3: Secreted |
Alternative Protein Names | Cell Surface Glycoprotein Cd200 Receptor 1 proteinCd200 Cell Surface Glycoprotein Receptor proteinCell Surface Glycoprotein Ox2 Receptor 1 proteinCD200R1 proteinCD200R proteinCRTR2 proteinMOX2R proteinOX2R proteinUNQ2522 proteinPRO6015 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance