| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human CD200 at 2 Mu g/mL (100 Mu L/well) can bind Human CD200 R with a linear range of 0.058-8.34 ng/mL. |
| Gene Symbol: | CD200R1 |
| Gene ID: | 131450 |
| Uniprot ID: | MO2R1_HUMAN |
| Immunogen: | Recombinant Human CD200R1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala27-Leu266) of human CD200R/MOX2R (Accession #NP_620161.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | AAQPNNSLMLQTSKENHALA SSSLCMDEKQITQNYSKVLA EVNTSWPVKMATNAVLCCPP IALRNLIIITWEIILRGQPS CTKAYRKETNETKETNCTDE RITWVSRPDQNSDLQIRTVA ITHDGYYRCIMVTPDGNFHR GYHLQVLVTPEVTLFQNRNR TAVCKAVAGKPAAHISWIPE GDCATKQEYWSNGTVTVKST CHWEVHNVSTVTCHVSHLTG NKSLYIELLPVPGAKKSAK |
| Function | Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. |
| Protein Name | Cell Surface Glycoprotein Cd200 Receptor 1Cd200 Cell Surface Glycoprotein ReceptorCell Surface Glycoprotein Ox2 Receptor 1 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Cell MembraneIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Protein Names | Cell Surface Glycoprotein Cd200 Receptor 1 proteinCd200 Cell Surface Glycoprotein Receptor proteinCell Surface Glycoprotein Ox2 Receptor 1 proteinCD200R1 proteinCD200R proteinCRTR2 proteinMOX2R proteinOX2R proteinUNQ2522 proteinPRO6015 protein |
Information sourced from Uniprot.org