| Short Description : | Recombinant-Human CD2-C-His protein was developed in hek293 cells using the region Lys 25-Asp 209. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA.Immobilized Human CD2 at 2 Mu g/mL (100 Mu L/well) can bind Human CD58 with a linear range of 1.22-34.4 ng/mL. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CD2 |
| Gene ID: | 914 |
| Uniprot ID: | CD2_HUMAN |
| Immunogen: | Recombinant Human CD2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys 25-Asp 209 ) of human CD2 (Accession #NP_001758.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Lys 25-Asp 209 |
| Immunogen Sequence: | KEITNALETWGALGQDINLD IPSFQMSDDIDDIKWEKTSD KKKIAQFRKEKETFKEKDTY KLFKNGTLKIKHLKTDDQDI YKVSIYDTKGKNVLEKIFDL KIQERVSKPKISWTCINTTL TCEVMNGTDPELNLYQDGKH LKLSQRVITHKWTTSLSAKF KCTAGNKVSKESSVEPVSCP EKGLD |
| Tissue Specificity | Expressed in natural killer cells (at protein level). |
| Function | CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. |
| Protein Name | T-Cell Surface Antigen Cd2Erythrocyte ReceptorLfa-2Lfa-3 ReceptorRosette ReceptorT-Cell Surface Antigen T11/Leu-5Cd Antigen Cd2 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | T-Cell Surface Antigen Cd2 proteinErythrocyte Receptor proteinLfa-2 proteinLfa-3 Receptor proteinRosette Receptor proteinT-Cell Surface Antigen T11/Leu-5 proteinCd Antigen Cd2 proteinCD2 proteinSRBC protein |
Information sourced from Uniprot.org
