Human CD177 protein (Recombinant) (N-His) (STJP005702)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD177-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CD177 |
| Gene ID | 57126 |
| Uniprot ID | CD177_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys133-Ser301 |
Additional Info
| Post Translational Modifications | N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). |
| Function | In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis. |
| Protein Name | Cd177 AntigenHuman Neutrophil Alloantigen 2aHna-2aNb1 GlycoproteinNb1 GpPolycythemia Rubra Vera Protein 1Prv-1Cd Antigen Cd177 |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftGpi-Like-AnchorSecretedCytoplasmic Granule MembraneCell ProjectionLamellipodiumCell Surface Expression On Neutrophils Is Increased Upon Tnf-AlphaFmlp Or Cxcl8/Il8-Mediated StimulationIn NeutrophilsStored Predominantly In Secondary And Tertiary GranulesCan Also Be Shedded From The Cell MembraneLocalizes To Lamellar Protrusions In Spreading Neutrophils |
| Alternative Protein Names | Cd177 Antigen proteinHuman Neutrophil Alloantigen 2a proteinHna-2a proteinNb1 GlycoproteinNb1 Gp proteinPolycythemia Rubra Vera Protein 1 proteinPrv-1 proteinCd Antigen Cd177 proteinCD177 proteinNB1 proteinPRV1 proteinUNQ595 proteinPRO1181 protein |
Information sourced from Uniprot.org