| Short Description : | Recombinant-Active-Human CD172b/SIRPB1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | When recombinant human CD172b/SIRPB1 is Immobilised at 1 µg/mL (100 µL/well) , recombinant human SP‑D binds with an ED50 of 0.1-0.8 Mu g/mL. |
| Gene Symbol: | SIRPB1 |
| Gene ID: | 10326 |
| Uniprot ID: | SIRB1_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Glu30-Leu371 |
| Post Translational Modifications | N-glycosylated. |
| Function | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP. |
| Protein Name | Signal-Regulatory Protein Beta-1Sirp-Beta-1Cd172 Antigen-Like Family Member BCd Antigen Cd172b |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-391160Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Signal-Regulatory Protein Beta-1 proteinSirp-Beta-1 proteinCd172 Antigen-Like Family Member B proteinCd Antigen Cd172b proteinSIRPB1 protein |
Information sourced from Uniprot.org
