| Post Translational Modifications | N-glycosylated. Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC.this is required for activation and subsequent autophosphorylation on additional tyrosine residues. |
| Function | Tyrosine kinase involved in the regulation of tissues remodeling. It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. |
| Protein Name | Discoidin Domain-Containing Receptor 2Discoidin Domain Receptor 2Cd167 Antigen-Like Family Member BDiscoidin Domain-Containing Receptor Tyrosine Kinase 2Neurotrophic Tyrosine Kinase - Receptor-Related 3Receptor Protein-Tyrosine Kinase TktTyrosine-Protein Kinase Tyro10Cd Antigen Cd167b |
| Database Links | Reactome: R-HSA-3000171 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Discoidin Domain-Containing Receptor 2 proteinDiscoidin Domain Receptor 2 proteinCd167 Antigen-Like Family Member B proteinDiscoidin Domain-Containing Receptor Tyrosine Kinase 2 proteinNeurotrophic Tyrosine Kinase - Receptor-Related 3 proteinReceptor Protein-Tyrosine Kinase Tkt proteinTyrosine-Protein Kinase Tyro10 proteinCd Antigen Cd167b proteinDDR2 proteinNTRKR3 proteinTKT proteinTYRO10 protein |
Information sourced from Uniprot.org
