Human CD161/KLRB1 protein (Recombinant) (C-His) (STJP007090)

SKU:
STJP007090
£469.50 - £2,492.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD161/KLRB1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: KLRB1
Gene ID: 3820
Uniprot ID: KLRB1_HUMAN
Immunogen Region: Lys68-Ser225
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Contains sialic acid residues.
Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein Name Killer Cell Lectin-Like Receptor Subfamily B Member 1
C-Type Lectin Domain Family 5 Member B
Hnkr-P1a
Nkr-P1a
Natural Killer Cell Surface Protein P1a
Cd Antigen Cd161
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Killer Cell Lectin-Like Receptor Subfamily B Member 1 protein
C-Type Lectin Domain Family 5 Member B protein
Hnkr-P1a protein
Nkr-P1a protein
Natural Killer Cell Surface Protein P1a protein
Cd Antigen Cd161 protein
KLRB1 protein
CLEC5B protein
NKRP1A protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005271 Human CD161/KLRB1 protein (Recombinant) (N-His) (STJP005271) E. coli
STJP005272 Human CD161/KLRB1 protein (Recombinant) (N-Fc) (STJP005272) Mammalian Cells
STJP008623 Human CD161/KLRB1 protein (Recombinant) (N-Fc) (STJP008623) Mammalian Cells
STJP012088 Human CD161/KLRB1 protein (Recombinant-Active) (N-hFc) (STJP012088) Mammalian Cells
STJP001541 Human CD161 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001541) HEK293

Related Products

!